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KMID : 0545120050150010112
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Journal of Microbiology and Biotechnology
2005 Volume.15 No. 1 p.112 ~ p.117
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Griseofulvin from Xylaria sp. Strain F0010, an Endophytic Fungus of Abies holophylla and its Antifungal Activity Against Plant Pathogenic Fungi
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Park JH
Choi GJ/Lee HB/Kim KM/Jung HS/Lee SW/Jang KS/Cho KY/Kim JC
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Abstract
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Griseofulvin has been used as an antifungal antibiotic for the treatment of mycotic diseases of humans and veterinary animals. The purpose of this work was to identify a griseofulvin-producing endophytic fungus from Abies holophylla and evaluate its in vivo antifungal activity against plant pathogenic fungi. Based on nuclear ribosomal ITS1-5.8SITS2 sequence analysis the fungus was identified and labeled as Xylaria sp. F0010. Two antifungal substances were purified from liquid cultures of Xylaria sp. F0010 and their chemical identities were determined to be griseofulvin and dechlorogriseofulvin through mass and NMR spectral analyses. Compared to dechlorogriseofulvin griseofulvin showed high in vivo and in vitro antifungal activity and effectively controlled the development of rice blast (Magnaporthe grisea) rice sheath blight (Corticium sasaki) wheat leaf rust (Puccinia recondita) and barley powdery mildew (Blumeria graminis f. sp. hordei) at doses of 50 to 150 μg/ml depending on the disease. This is the first report on the production of griseofulvin and dechlorogriseofulvin by Xylaria species.
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